X chromosome drive

X chromosome drive

How are toxic proteins cleared by microglia? Since microglia are the macrophages of the CNS, the promotion of an increase in their ability to phagocytose highly toxic proteins is a promising new therapeutic approach to prevent many diseases. Toxic proteins are produced in a variety of brain diseases, such as Alzheimer’s disease (b-amyloid), amyotrophic lateral sclerosis (superoxide dismutase 1)...

X Chromosome Inactivation in Opioid Addicted Women

Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...

Sex Chromosome Meiotic Drive

Intragenomic Conflict and Immune Tolerance: Do Selfish X-Linked Alleles Drive Skewed X Chromosome Inactivation?

In mammalian females, diploid somatic cells contain two X chromosomes, one of which is transcriptionally silenced, in a process termed X chromosome inactivation (XCI). Whereas XCI is largely random in placental females, many women exhibit skewed XCI (SXCI), in which the vast majority cells have the same X chromosome inactivated. SXCI has serious health consequences, associated with conditions r...

x chromosome inactivation

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